@article {23, title = {Incidence and Assessment of Adverse Drug Reactions at a Tertiary Care Hospital}, journal = {Journal of Pharmacy Practice and Community Medicine}, volume = {6}, year = {2020}, month = {April 2020}, pages = {15-17}, type = {Short Communication}, chapter = {15}, abstract = {

Background: Adverse drug reactions have proved a significant problem in healthcare for decade. Healthcare professionals have a responsibility in use of rational drugs for their patients. Objectives: The aim of the study was to determine the prevalence of ADRs in a tertiary care hospital to determine the most common Therapeutic Class of Drugs causing ADR and to determine the most common Organ system affected by ADR. Methods: The Prospective, observational study was conducted in the wards of St. Philomena{\textquoteright}s Hospital, Bangalore between January 2016 and August 2016. All In-patients were monitored for ADRs during their admission period. Results: Over the study period of 12 months, a total of 374 ADRs were reported in 600 patients. The ADRs observed were higher in female patients [196 (52.4\%)]. A predominance of gastro- intestinal reactions [70 (18.71\%)] was observed. Therapeutic classes of drugs frequently associated with ADRs were antibiotics [84(22.4\%)] followed by antihypertensive agents [63 (16.84\%)] and antidiabetic [37 (9.89\%)]. The most common drugs involved in causing ADRs were Furosemide and Cefoperazone and the most commonly reported ADR was Diarrhoea [28 (7.4.8\%)] followed by Itching 2[9 (7.75\%)]. Majority of the ADRs [95 (74.80\%)] were managed by withdrawing the suspected drug. The causality assessment of the ADRs were carried out using the Naranjo{\textquoteright}s Scale algorithm and the majority of the ADRs were found to be definite [41 (32\%)]. Conclusion: Continuous monitoring by a clinical pharmacist in hospital setup will reduce the occurrence of ADR and improve the patient safety.

}, keywords = {Adverse drug reaction, Causality assessment, Naranjo scale, Patient safety, Pharmacovigilance}, doi = {10.5530/jppcm.2020.1.5}, author = {Pulimi Divya Priyanka and T. Vithya and Shobha Rani Rajeev Hiremath and Shankar Prasad} }