@article {79,
	title = {A Case Report on Bupivacaine Induced Limb Weakness; Type I  Augmented Adverse Drug Reaction (ADR)},
	journal = {Journal of Pharmacy Practice and Community Medicine},
	volume = {8},
	year = {2022},
	month = {May 2022},
	pages = {18-19},
	type = {Case Report},
	chapter = {18},
	abstract = {<p class="rtejustify">Bupivacaine is an amide-type, long-acting local anesthetic. It acts by preventing generation or conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold. Lower limb motor weakness is a well-known complication of epidural analgesia with local anesthetics. In this case report a 60yr old female developed Bupivacaine induced lower limb weakness post-surgery. This event was identified as Type 1 augmented ADR which was assessed and reported with the help of Naranjo ADR scale. The dose of Bupivacaine was reduced as per clinical pharmacist{\textquoteright}s suggestion and that helped in recovery from the weakness on the same day. Type 1 augmented ADR is related to the pharmacological action of the drug or due to the exaggerated pharmacologic response.</p>
},
	keywords = {ADR, Bupivacaine, Epidural analgesic, Limb weakness, Naranjo scale.},
	doi = {10.5530/jppcm.2022.1.5},
	author = {Jeffin Gloria John}
}
@article {81,
	title = {Case Series on Teicoplanin Induced Thrombocytopenia {\textendash} An Issue of Concern},
	journal = {Journal of Pharmacy Practice and Community Medicine},
	volume = {8},
	year = {2022},
	month = {August 2022},
	pages = {34-35},
	type = {Case Series},
	chapter = {34},
	abstract = {<p class="rtejustify">Teicoplanin is a glycopeptide antibiotic which inhibits peptidoglycan polymerization in gram-positive bacteria resulting in their cell death. Thrombocytopenia is a blood disorder in which platelet count falls below 100,000 cells/μl. Bleeding occurs when platelet falls below 20,000 cells/μl. In this case series, three patients with different clinical scenarios are explained who developed thrombocytopenia associated with teicoplanin administration during their course of medication. They were identified, assessed and reported for the ADR with the help of Naranjo ADR probability scale. As far as to our knowledge teicoplanin induced thrombocytopenia is not much studied and reported. In a current emerging use of higher antibiotics like teicoplanin, this is a serious life-threatening condition that has to be carefully monitored while on treatment with these types of higher antibiotics.</p>
},
	keywords = {ADR, Drug induced thrombocytopenia, Haemolytic anaemia., Naranjo scale, Teicoplanin},
	doi = {10.5530/jppcm.2022.2.8},
	author = {Mohamed Aamir ZS}
}
