@article {81, title = {Case Series on Teicoplanin Induced Thrombocytopenia {\textendash} An Issue of Concern}, journal = {Journal of Pharmacy Practice and Community Medicine}, volume = {8}, year = {2022}, month = {August 2022}, pages = {34-35}, type = {Case Series}, chapter = {34}, abstract = {

Teicoplanin is a glycopeptide antibiotic which inhibits peptidoglycan polymerization in gram-positive bacteria resulting in their cell death. Thrombocytopenia is a blood disorder in which platelet count falls below 100,000 cells/μl. Bleeding occurs when platelet falls below 20,000 cells/μl. In this case series, three patients with different clinical scenarios are explained who developed thrombocytopenia associated with teicoplanin administration during their course of medication. They were identified, assessed and reported for the ADR with the help of Naranjo ADR probability scale. As far as to our knowledge teicoplanin induced thrombocytopenia is not much studied and reported. In a current emerging use of higher antibiotics like teicoplanin, this is a serious life-threatening condition that has to be carefully monitored while on treatment with these types of higher antibiotics.

}, keywords = {ADR, Drug induced thrombocytopenia, Haemolytic anaemia., Naranjo scale, Teicoplanin}, doi = {10.5530/jppcm.2022.2.8}, author = {Mohamed Aamir ZS} } @article {23, title = {Incidence and Assessment of Adverse Drug Reactions at a Tertiary Care Hospital}, journal = {Journal of Pharmacy Practice and Community Medicine}, volume = {6}, year = {2020}, month = {April 2020}, pages = {15-17}, type = {Short Communication}, chapter = {15}, abstract = {

Background: Adverse drug reactions have proved a significant problem in healthcare for decade. Healthcare professionals have a responsibility in use of rational drugs for their patients. Objectives: The aim of the study was to determine the prevalence of ADRs in a tertiary care hospital to determine the most common Therapeutic Class of Drugs causing ADR and to determine the most common Organ system affected by ADR. Methods: The Prospective, observational study was conducted in the wards of St. Philomena{\textquoteright}s Hospital, Bangalore between January 2016 and August 2016. All In-patients were monitored for ADRs during their admission period. Results: Over the study period of 12 months, a total of 374 ADRs were reported in 600 patients. The ADRs observed were higher in female patients [196 (52.4\%)]. A predominance of gastro- intestinal reactions [70 (18.71\%)] was observed. Therapeutic classes of drugs frequently associated with ADRs were antibiotics [84(22.4\%)] followed by antihypertensive agents [63 (16.84\%)] and antidiabetic [37 (9.89\%)]. The most common drugs involved in causing ADRs were Furosemide and Cefoperazone and the most commonly reported ADR was Diarrhoea [28 (7.4.8\%)] followed by Itching 2[9 (7.75\%)]. Majority of the ADRs [95 (74.80\%)] were managed by withdrawing the suspected drug. The causality assessment of the ADRs were carried out using the Naranjo{\textquoteright}s Scale algorithm and the majority of the ADRs were found to be definite [41 (32\%)]. Conclusion: Continuous monitoring by a clinical pharmacist in hospital setup will reduce the occurrence of ADR and improve the patient safety.

}, keywords = {Adverse drug reaction, Causality assessment, Naranjo scale, Patient safety, Pharmacovigilance}, doi = {10.5530/jppcm.2020.1.5}, author = {Pulimi Divya Priyanka and T. Vithya and Shobha Rani Rajeev Hiremath and Shankar Prasad} }