01410nas a2200193   4500008004100000245010200041210006900143260001300212300001000225490000600235520081800241653000801059653001601067653002301083653001801106653001901124100002501143856004801168       2022                        eng d00aA Case Report on Bupivacaine Induced Limb Weakness; Type I  Augmented Adverse Drug Reaction (ADR)0 aCase Report on Bupivacaine Induced Limb Weakness Type I Augmente  cMay 2022  a18-190 v83 a<p class="rtejustify">Bupivacaine is an amide-type, long-acting local anesthetic. It acts by preventing generation or conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold. Lower limb motor weakness is a well-known complication of epidural analgesia with local anesthetics. In this case report a 60yr old female developed Bupivacaine induced lower limb weakness post-surgery. This event was identified as Type 1 augmented ADR which was assessed and reported with the help of Naranjo ADR scale. The dose of Bupivacaine was reduced as per clinical pharmacist’s suggestion and that helped in recovery from the weakness on the same day. Type 1 augmented ADR is related to the pharmacological action of the drug or due to the exaggerated pharmacologic response.</p>
10aADR10aBupivacaine10aEpidural analgesic10aLimb weakness10aNaranjo scale.1 aJohn, Jeffin, Gloria  uhttp://www.jppcm.org/article/2022/8/1/18-1901513nas a2200193   4500008004100000245008000041210006900121260001600190300001000206490000600216520092600222653000801148653003401156653002401190653001801214653001601232100002301248856004801271       2022                        eng d00aCase Series on Teicoplanin Induced Thrombocytopenia – An Issue of Concern0 aCase Series on Teicoplanin Induced Thrombocytopenia An Issue of   cAugust 2022  a34-350 v83 a<p class="rtejustify">Teicoplanin is a glycopeptide antibiotic which inhibits peptidoglycan polymerization in gram-positive bacteria resulting in their cell death. Thrombocytopenia is a blood disorder in which platelet count falls below 100,000 cells/μl. Bleeding occurs when platelet falls below 20,000 cells/μl. In this case series, three patients with different clinical scenarios are explained who developed thrombocytopenia associated with teicoplanin administration during their course of medication. They were identified, assessed and reported for the ADR with the help of Naranjo ADR probability scale. As far as to our knowledge teicoplanin induced thrombocytopenia is not much studied and reported. In a current emerging use of higher antibiotics like teicoplanin, this is a serious life-threatening condition that has to be carefully monitored while on treatment with these types of higher antibiotics.</p>
10aADR10aDrug induced thrombocytopenia10aHaemolytic anaemia.10aNaranjo scale10aTeicoplanin1 aZS, Mohamed, Aamir  uhttp://www.jppcm.org/article/2022/8/2/34-35