Skin aging and hyperpigmentation are primarily driven by oxidative stress, collagen degradation, ultraviolet exposure, and environmental factors, necessitating multifunctional cosmeceutical formulations with synergistic mechanisms of action.
To develop and optimize a Carbopol® 940-based multifunctional cosmeceutical hydrogel containing niacinamide, Sodium Ascorbyl Phosphate (SAP), hyaluronic acid,Aloe vera, andCamellia sinensis extracts for antiaging and skin-brightening applications.
Three hydrogel Formulations (F1-F3) with varying Carbopol® 940 concentrations (0.75-1.25% wt/wt) were prepared using controlled hydration and neutralization techniques. Formulations were evaluated for physicochemical characteristics, pH, viscosity (Brookfield DV-II+, spindle 64, 10 r.p.m.), spreadability, rheological behavior,in vitro antioxidant activity (DPPH assay), accelerated stability (40°C/75% RH for 90 days), and primary skin irritation (n = 6 healthy volunteers). Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test (p < 0.05).
The optimized formulation (F2, 1.0% Carbopol®) exhibited pH 5.9 ±0.1, viscosity 4,850 ± 120 cP, and spreadability 6.8 ± 0.2 g cm/s, indicating optimal topical rheology. F2 demonstrated significant antioxidant activity (78.4 ± 1.6% DPPH inhibition), comparable to ascorbic acid, 94.2 ± 0.8% and significantly higher than placebo gel (8.3 ± 1.2%) (p < 0.001). Accelerated stability studies showed no significant changes in pH, viscosity, or spreadability over 90 days (p > 0.05). The Primary Irritation Index was 0.00, confirming dermatologic safety.
The optimized multifunctional hydrogel (F2) demonstrated excellent stability, safety, antioxidant activity, and optimal rheological performance. The synergistic combination of niacinamide, SAP, hyaluronic acid, and herbal antioxidants provides a promising cosmeceutical platform for antiaging and skin-brightening applications pending clinical validation.
Abstract
Share on Mobile
Scan to access on mobile
Keywords
Cosmeceutical
Hydrogel
Antiaging
Skin Brightening
Niacinamide
Sodium Ascorbyl Phosphate
Hyaluronic Acid
Antioxidant
Topical Delivery
Stability Study
Content
No content available